Promethazine HCl and Codeine Phosphate Oral Option ought to be applied with caution in clients with bone- marrow depression. Leukopenia and agranulocytosis are reported, normally when promethazine has been Utilized in association with other known marrow-toxic agents.
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Tend not to drink Liquor or use prescription or in excess of-the-counter medicines that consist of Liquor. Using Alcoholic beverages although getting promethazine/codeine might cause you to definitely overdose and die.
Due to the possibility of respiratory despair, stay away from the usage of opioid antitussives, which include Promethazine HCl and Codeine Phosphate Oral Alternative in patients with compromised respiratory perform, sufferers susceptible to respiratory failure, and in aged, cachectic, or debilitated individuals.
Codeine: In clients getting MAO inhibitors, an Original tiny test dose is highly recommended to allow observation of any abnormal narcotic effects or MAOI interaction.
Promethazine and codeine must be applied all through pregnancy provided that the opportunity benefit justifies the potential danger for the fetus.
Like other codeine solutions, codeine linctus might be routine-forming and may lead to habit or overdose.
Human Facts Posted information from situation-control and observational reports on codeine use throughout pregnancy are inconsistent within their results. Some scientific get more info tests of codeine exposure confirmed an increased possibility of General congenital malformations while some did not.
Respiratory despair leading to arrest, coma, and Demise has website transpired with the usage of codeine antitussives in younger small children, particularly during the less than-a read more person-calendar year infants whose power to deactivate the drug is not really absolutely formulated.
Dr Cave additional: check here “Codeine dependancy generally is a gradual method. Should you have been using it for a long period and want to halt, you may discuss with your healthcare provider and reduce the amount you're taking gradually.
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Codeine has superior antitussive exercise, Whilst less than that of morphine at equal doses. It is Employed in preference to morphine, simply because Uncomfortable side effects are infrequent at the standard antitussive dose of codeine.
The concomitant utilization of opioids with other click here medicines that influence the serotonergic neurotransmitter technique has resulted in serotonin syndrome.